Effects of Asymmetric Nanopore Geometries on Nanoparticle Sensing Using Track-Etched Nanopore Membranes

Resistive pulse sensing, based on the Coulter Counter principle, is an important assay for sensing and separation processes to detect/discriminate several types of particles in various mediums. In such a set-up, attaining signal from smaller can be hard compared larger particles. this work, we focus critical role pore shape precision. We have simulated hourglass cigar shaped nanopores study sensitivity small considered translocation 120 nm diameter particle by altering surface charge as -0.001 C/m2, -0.007 C/m2 -0.015 under applied potential between -0.3 V -1 with 0.1 increments. signals different concentration identical-sized varying charges. Comparison magnitudes normalized current changes obtained each shapes shown that yields more prominent sized than pore. The results reveal provides higher discriminate might preferable nanopore sensor applications.